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XRCC1 antibody [33-2-5]

Anti-XRCC1 antibody [33-2-5] used in IHC (Paraffin sections) (IHC-P). GTX21838

Cat. No. GTX21838

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 33-2-5

Isotype

 IgG2b

Application

 ICC/IF, IHC-P

Reactivity

 Human
Package
250 μl ($399)
See all XRCC1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P 1:50‐1:100

Note :

IHC-P
Recommendations for antigen retrieval : Citrate Buffer pH 6.0 at room temperature for 30 mins.
Not tested in other applications.

Calculated MW

69 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BALB/C mice were injected with recombinant human XRCC1 protein.

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_372882

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

X-ray repair cross complementing 1 , RCC , SCAR26

Cellular Localization

Nucleus

Background

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-XRCC1 antibody [33-2-5] used in IHC (Paraffin sections) (IHC-P). GTX21838

GTX21838 IHC-P Image

IHC-P analysis of human testis tissue using GTX21838 XRCC1 antibody [33-2-5].

REFERENCE

Application Reference

Kong X et al. PLoS One 2011; 6 (8) : e23548 Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.
Kong X et al. Nucleic Acids Res 2009; 37 (9) : e68 Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells.
Application : ICC/IF

Clone Reference

Shamanna RA et al. Nat Commun 2016; 7:13785 WRN regulates pathway choice between classical and alternative non-homologous end joining.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399