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c-Abl (phospho Tyr393/Tyr429) antibody

Anti-c-Abl (phospho Tyr393/Tyr429) antibody used in IHC (Paraffin sections) (IHC-P). GTX79153

Cat. No. GTX79153

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P

Reactivity

Human
Package
100 μg ($399)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

123 kDa. ( Note )

Predict Reactivity

Mouse(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human
ABL1/2 around the phosphorylation site of tyrosine 393/429 (D-T-Yp-T-A).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

RRID

AB_11165659

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ABL,ABL protooncogene 1, nonreceptor tyrosine kinase,ABL1,JTK7,bcr/abl,cABL,cABL1,p150,vabl,c-Abl,ABL proto-oncogene 1, non-receptor tyrosine kinase

Cellular Localization

Cytoplasm,Cytoskeleton,Nucleus,Mitochondrion,Nucleus membrane

Background

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

Database

Research Area

DATA IMAGES

Anti-c-Abl (phospho Tyr393/Tyr429) antibody used in IHC (Paraffin sections) (IHC-P). GTX79153

GTX79153 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX79153 c-Abl (phospho Tyr393/Tyr429) antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399