Antibodies for O-GlcNAcylation Research: O-GlcNAc transferase (OGT)

O-GlcNAcylation is a posttranslational modification (PTM) linking the monosaccharide N-acetylglucosamine (GlcNAc) to serine and threonine residues of various proteins through an O-linked glycosidic bond. O-GlcNAc addition, and removal, is a highly regulated process dependent on different factors including substrate UDP-GlcNAc levels, nutrient and stress conditions, and the respective activities of the enzymes that add (O-GlcNAc transferase (OGT)) or remove (O-GlcNAcase (OGA)) O-GlcNAc to/from target proteins (1). The significance of O-GlcNAcylation for both normal homeostatic mechanisms, as well as for a spectrum of pathological states, has stimulated the search for inhibitors of both OGT and OGA for both research and potential therapeutic applications (1, 2).

To support O-GlcNAcylation research, GeneTex has added two new OGT recombinant rabbit monoclonal antibodies (GTX637222 and GTX637223), each validated for several applications, to its catalog of OGT reagents (see below). To learn more about GeneTex’s complete product listing, please visit our website at www.genetex.com.