APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.1 - 0.4 μg/ml |
10-20μg antibody/mg lysate |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
Tris-Citrate/Phosphate
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide representing a portion of the protein encoded within exon 53 (LocusLink ID 472).
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
AT1 , ATA , ATC , ATD , ATDC , ATE , ATM , ATM serine/threonine kinase , TEL1 , TELO1
Cellular Localization
Nucleus,Cytoplasmic vesicle
Background
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Database
Research Area
REFERENCE
There are currently no references for ATM antibody (GTX22631). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for ATM antibody (GTX22631). Be the first to share your experience with this product.