APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:25 |
|
Note :
IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retrieval Solution pH 9.
|
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
Tissue culture supernatant
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Antigen Species
Human
Immunogen
Prokaryotic recombinant protein of 321 amino acids representing the N-terminus of the human androgen receptor.
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
androgen receptor , AIS , AR8 , DHTR , HUMARA , HYSP1 , KD , NR3C4 , SBMA , SMAX1 , TFM
Cellular Localization
Nucleus , Cytoplasm
Background
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Database
Research Area
DATA IMAGES
![Anti-Androgen Receptor antibody [AR27] used in IHC (Paraffin sections) (IHC-P). GTX01898](/templates/default/js/lightbox/images/loading.gif "Anti-Androgen Receptor antibody [AR27] used in IHC (Paraffin sections) (IHC-P). GTX01898")
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GTX01898 IHC-P Image
IHC-P analysis of human skin using GTX01898 Androgen Receptor antibody [AR27]. Note the nuclear staining of the epithelial cells.
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REFERENCE
There are currently no references for Androgen Receptor antibody [AR27] (GTX01898). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Androgen Receptor antibody [AR27] (GTX01898). Be the first to share your experience with this product.
![Anti-Androgen Receptor antibody [AR27] used in IHC (Paraffin sections) (IHC-P). GTX01898](/upload/website/prouct_img/small/GTX01898/GTX01898_20200811_IHC-P_100_w_23053121_994.webp "Anti-Androgen Receptor antibody [AR27] used in IHC (Paraffin sections) (IHC-P). GTX01898")
![Anti-Androgen Receptor antibody [AR27] used in IHC (Paraffin sections) (IHC-P). GTX01898](/upload/website/prouct_img/normal/GTX01898/GTX01898_20200811_IHC-P_100_w_23053121_994.webp "Anti-Androgen Receptor antibody [AR27] used in IHC (Paraffin sections) (IHC-P). GTX01898")