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CD74 antibody [LN2] (ready-to-use)

Anti-CD74 antibody [LN2] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX73535

Cat. No. GTX73535

Reference 4

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 LN2

Isotype

 IgG1

Application

 WB, IHC-P, IHC-Fr, Functional Assay

Reactivity

 Human
Package
6 ml ($409)
See all CD74 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
Functional Assay Assay dependent

Note :

IHC-P
Recommendations for antigen retrieval : Citrate Buffer pH 6.0 at room temperature for 30 mins.
Not tested in other applications.

Calculated MW

34 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

SU-DHL-4 lymphoma cells.

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_374976

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD74 molecule , DHLAG , HLADG , II , Ia-GAMMA , p33

Cellular Localization

Cell membrane , Endoplasmic reticulum membrane , Endosome , Lysosome

Background

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Database

Research Area

DATA IMAGES

Anti-CD74 antibody [LN2] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX73535

GTX73535 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX73535 CD74 antibody [LN2] (ready-to-use).

REFERENCE

Clone Reference

S Ebert et al. Cells 2023; 12 (14):1899 Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation
Application : Functional Assay
Z Berkova et al. Exp Clin Cancer Res 2014; 33 (1):80 CD74 interferes with the expression of fas receptor on the surface of lymphoma cells
Application : WB
M McClelland et al. Am J Pathol 2009; 174 (2):638-46 Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer
Application : IHC-P
Pack M et al. Immunology 2008; 123 (3):438-46 DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp.
Application : IHC-Fr
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409