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Caspase 12 antibody

Anti-Caspase 12 antibody used in IHC (Paraffin sections) (IHC-P). GTX12333
Anti-Caspase 12 antibody used in Western Blot (WB). GTX12333
Anti-Caspase 12 antibody used in IHC (Paraffin sections) (IHC-P). GTX12333

Cat. No. GTX12333

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($449)
See all Caspase 12 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.1-0.5μg/ml
IHC-P 0.5-1μg/ml
Not tested in other applications.

Calculated MW

38.87 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.1% Na₂HPO₄, 0.45% NaCl, 2.5% BSA

Preservative

0.025% Thimerosal, 0.025% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

500 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12(71-84aa KIFREHLWNSKKQL).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Background

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-Caspase 12 antibody used in IHC (Paraffin sections) (IHC-P). GTX12333

GTX12333 IHC-P Image

IHC-P analysis of human mammary cancer tissue using GTX12333 Caspase 12 antibody.

Anti-Caspase 12 antibody used in Western Blot (WB). GTX12333

GTX12333 WB Image

WB analysis of various samples using GTX12333 Caspase 12 antibody.
Lane 1 : PANC whole cell lysate at 40ug
Lane 2 : SMMC whole cell lysate at 40ug
Lane 3 : A549 whole cell lysate at 40ug
Lane 4 : HeLa whole cell lysate at 40ug
Dilution : 0.5 μg/mL

Anti-Caspase 12 antibody used in IHC (Paraffin sections) (IHC-P). GTX12333

GTX12333 IHC-P Image

IHC-P analysis of human lung cancer tissue using GTX12333 Caspase 12 antibody.

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Thimerosal.pdf
Package List Price ($)
$ 449