APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.5 - 2 μg/mL |
5 μg/mL |
Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
SK-N-SH Cell Lysate(GTX23956) , HeLa Cell Slide(GTX25529)
Product Note
At least four isoforms of DISC1 are known to exist; this antibody will detect the three longest isoforms.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
DISC1 antibody was raised against an 18 amino acid synthetic peptide from near the center of human DISC1.The immunogen is located within amino acids 350 - 400 of DISC1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
DISC1 scaffold protein , C1orf136 , SCZD9
Cellular Localization
Cytoplasm,Cytoplasm, cytoskeleton,Mitochondrion
Background
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX31320 WB Image
WB analysis of SK-N-SH cell lysate using GTX31320 DISC1 antibody. Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml
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GTX31320 ICC/IF Image
ICC/IF analysis of HeLa cells using GTX31320 DISC1 antibody. Working concentration : 20 μg/ml
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GTX31320 ICC/IF Image
ICC/IF analysis of HeLa cells using GTX31320 DISC1 antibody. Working concentration : 5 μg/ml
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REFERENCE
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REVIEW
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