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IKB beta peptide

Cat. No. GTX27548

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($189)
See all IKB beta products

APPLICATION

Application Note

For BL: Intended for use as a control peptide when used with anti-IkB beta (C-terminal specific GTX27548) to block specific interaction of anti-IkB beta (C-terminal specific) with the IkB beta subunit. Control peptide should be used at 1.0 mg per 1.0 ml of antiserum in per assay. Optimal dilutions/concentrations should be determined by the researcher.

PROPERTIES

Form

Liquid

Buffer

Batch dependent

Preservative

0.01% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Purity

> 95%

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Background

Three major forms of IkB-like molecules have been identified and each is characterized by multiple copies of ankyrin repeats. IkB-alpha and IkB-beta appear to be the major regulatory forms of IkB in most cells. These proteins interact with p65 or c-Rel containing forms of NFkB and block nuclear import by masking the nuclear localization sequences of NFkB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IkB. Immunoblotting easily detects the hyper-phosphorylated forms of IkB-alpha, but not phosphorylated IkB-beta. Interestingly, IkB-alpha and IkB-beta mediate different NFkB responses. IkB-alpha appears to control more transient activation of NFkB in response to an inducer, while IkB-beta controls a persistent response. Bcl-3 interacts with p50 and p52 containing forms of NFkB, but rather than being an inhibitor it appears to function to stimulate transcription. The degradation of IkB is confirmed by immunoblotting.

Research Area

REFERENCE

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 189