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PDE4D5 antibody

KO/KD
Anti-PDE4D5 antibody used in Western Blot (WB). GTX14626

Cat. No. GTX14626

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IP, ELISA, IHC

Reactivity

 Human, Mouse, Rat, Rabbit
Package
100 μg ($419)
See all PDE4D5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
ICC/IF 1:200
IP 1:150
ELISA 1:10000
IHC 1:200
Not tested in other applications.

Calculated MW

91 kDa. ( Note )

Product Note

This antibody does not cross-react with other members of the PDE4D family or with other PDE4 proteins (PDE4A, PDE4B and PDE4C) or with other PDE family members.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.65 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

A 20 amino acid synthetic peptide taken from the N-terminus corresopnding to the PDE4D5 variant.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_368861

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 4D , ACRDYS2 , DPDE3 , HSPDE4D , PDE43 , PDE4DN2 , STRK1

Cellular Localization

Apical cell membrane , Cytoplasm , Membrane , Cytoplasm, cytoskeleton

Background

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

Database

Research Area

DATA IMAGES

Anti-PDE4D5 antibody used in Western Blot (WB). GTX14626

GTX14626 WB Image

KO/KD

The data was published in the journal J Mol Signal in 2012. PMID: 22583680

REFERENCE

Application Reference

Kocer SS et al. J Mol Signal 2012; 7 (1) : 4 "Shaping" of cell signaling via AKAP-tethered PDE4D: Probing with AKAR2-AKAP5 biosensor.
Application : WB
Reactivity : Human
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Package List Price ($)
$ 419