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Integrin beta 4 antibody

Anti-Integrin beta 4 antibody used in IHC (Paraffin sections) (IHC-P). GTX04496
Anti-Integrin beta 4 antibody used in IHC (Paraffin sections) (IHC-P). GTX04496
Anti-Integrin beta 4 antibody used in Western Blot (WB). GTX04496
Anti-Integrin beta 4 antibody used in IHC (Paraffin sections) (IHC-P). GTX04496
Anti-Integrin beta 4 antibody used in Flow cytometry (FACS). GTX04496

Cat. No. GTX04496

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, FACS, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($469)
See all Integrin beta 4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.1-0.25μg/ml
IHC-P 0.5-1μg/ml
FACS 1-3μg/1x10⁶ cells
ELISA 0.1-0.5μg/ml
Not tested in other applications.

Calculated MW

202 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄

Preservative

0.01mg Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

E.coli-derived human Integrin beta 4/ITGB4 recombinant protein (R29-K431)

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin subunit beta 4 , CD104 , GP150

Cellular Localization

Cell membrane; Single-pass type I membrane protein , Cell junction, hemidesmosome

Background

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Integrin beta 4 antibody used in IHC (Paraffin sections) (IHC-P). GTX04496

GTX04496 IHC-P Image

IHC-P analysis of human lung cancer tissue using GTX04496 Integrin beta 4 antibody.
Antigen retrieval : Heat mediated EDTA buffer (pH 8.0)
Dilution : 1 μg/mL

Anti-Integrin beta 4 antibody used in IHC (Paraffin sections) (IHC-P). GTX04496

GTX04496 IHC-P Image

IHC-P analysis of human intestinal cancer tissue using GTX04496 Integrin beta 4 antibody.
Green : Primary antibody
Blue : DAPI
Antigen retrieval : Heat mediated EDTA buffer (pH 8.0)
Dilution : 4 μg/mL

Anti-Integrin beta 4 antibody used in Western Blot (WB). GTX04496

GTX04496 WB Image

WB analysis of various samples using GTX04496 Integrin beta 4 antibody.
Dilution : 0.25 μg/mL
Loading : 50 μg

Anti-Integrin beta 4 antibody used in IHC (Paraffin sections) (IHC-P). GTX04496

GTX04496 IHC-P Image

IHC-P analysis of human rectal cancer tissue using GTX04496 Integrin beta 4 antibody.
Antigen retrieval : Heat mediated EDTA buffer (pH 8.0)
Dilution : 1 μg/mL

Anti-Integrin beta 4 antibody used in Flow cytometry (FACS). GTX04496

GTX04496 FACS Image

FACS analysis of Raji cells using GTX04496 Integrin beta 4 antibody.
Blue : Primary antibody
Green : Isotype control
Red : Unlabelled sample
Dilution : 1μg/1x10⁶

REFERENCE

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REVIEW

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Package List Price ($)
$ 469