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MD2 antibody [18H10]

Cat. No. GTX54485

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 18H10

Isotype

 IgG2b

Application

 FACS, Functional Assay

Reactivity

 Human
Package
50 μg ($399)
See all MD2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Functional Assay Assay dependent
Not tested in other applications.

Calculated MW

19 kDa. ( Note )

Product Note

The monoclonal antibody 18H10 reacts with MD-2. However, it does not react with sMD-2. In addition, the monoclonal antibody 18H10 is able to inhibit bacterial binding to MD-2.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TLR4/MD-2 expressing CHO cells/ chimeric TLR4/MD-2 fusion protein

Purification

Purified IgG2b

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ESOP1,LY96,MD2,ly96,lymphocyte antigen 96,MD-2

Cellular Localization

Secreted,Extracellular space

Background

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399