APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1:1000 |
1:50-1:100 |
1:10-1:50 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KLH conjugated synthetic peptide between 186-215 amino acids from the C-terminal region of human MPZ.
Purification
Protein A purified, followed by peptide affinity purification.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
myelin protein zero , CHM , CHN2 , CMT1 , CMT1B , CMT2I , CMT2J , CMT4E , CMTDI3 , CMTDID , DSS , HMSNIB , MPP , P0
Cellular Localization
Cell membrane
Background
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]
Database
Research Area
DATA IMAGES
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GTX81135 IHC-P Image
IHC-P analysis of human brain tissue using GTX81135 MPZ antibody, C-term.
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GTX81135 WB Image
WB analysis of CEM cell lysate (35ug/lane) using GTX81135 MPZ antibody, C-term.
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GTX81135 WB Image
WB analysis of 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MPZ (Lane 2) using GTX81135 MPZ antibody, C-term.
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GTX81135 FACS Image
FACS analysis of CEM cells using GTX81135 MPZ antibody, C-term. Top histogram : negative control Bottom histogram : CEM cells
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REFERENCE
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REVIEW
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