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MPZ antibody

Anti-MPZ antibody used in Immunohistochemistry (IHC). GTX85466
Anti-MPZ antibody used in IHC (Paraffin sections) (IHC-P). GTX85466

Cat. No. GTX85466

Reference 1

Host

 Chicken

Clonality

 Polyclonal

Isotype

 IgY

Application

 WB, ICC/IF, IHC-P, IHC

Reactivity

 Human, Mouse, Rat
Package
50 μg ($399)
See all MPZ products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:10000-1:20000
ICC/IF Assay dependent
IHC-P Assay dependent
IHC 1:2000-1:5000
Not tested in other applications.

Calculated MW

28 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Chickens were immunized with two synthetic peptide / keyhole limpet hemocyanin (KLH) conjugates. These synthetic peptides corresponded to different regions of the Po gene product, but are shared between the human (NP_000521, NCBI) and mouse (NP_032649, NCBI) sequences.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

myelin protein zero , Mpp , P-zero , P0

Cellular Localization

Cell membrane

Background

This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015]

Database

Research Area

DATA IMAGES

Anti-MPZ antibody used in Immunohistochemistry (IHC). GTX85466

GTX85466 IHC Image

Po (green staining) can be seen in the myelin and Schwann cell processes surrounding the nodes of Ranvier. In this photomicrograph, rabbit antibodies against LAMP (lysozome-associated membrane glycoprotein) (red staining) serves as the counterstain, and DAPI (blue staining) allows visualization of nuclei.

Anti-MPZ antibody used in IHC (Paraffin sections) (IHC-P). GTX85466

GTX85466 IHC-P Image

IHC-P analysis of 4.0% paraformaldehyde-fixed tissue section through the sciatic nerve of an adult mouse using GTX85466 MPZ antibody.
Dilution : 1:1000

REFERENCE

Application Reference

Chung YF et al. Int J Mol Sci 2022; 23 (13) Human IL12p80 Promotes Murine Oligodendrocyte Differentiation to Repair Nerve Injury.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399