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Tyrosinase antibody

Anti-Tyrosinase antibody used in Western Blot (WB). GTX16389
Anti-Tyrosinase antibody used in IHC (Paraffin sections) (IHC-P). GTX16389
Anti-Tyrosinase antibody used in IHC (Paraffin sections) (IHC-P). GTX16389
Anti-Tyrosinase antibody used in IHC (Paraffin sections) (IHC-P). GTX16389
Anti-Tyrosinase antibody used in IHC (Paraffin sections) (IHC-P). GTX16389

Cat. No. GTX16389

Reference 3

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all Tyrosinase products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-340 of human TYR (NP_000363.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tyrosinase , ATN , CMM8 , OCA1 , OCA1A , OCAIA , SHEP3

Background

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES

Anti-Tyrosinase antibody used in Western Blot (WB). GTX16389

GTX16389 WB Image

WB analysis of various sample lysates using GTX16389 Tyrosinase antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-Tyrosinase antibody used in IHC (Paraffin sections) (IHC-P). GTX16389

GTX16389 IHC-P Image

IHC-P analysis of mouse skin tissue using GTX16389 Tyrosinase antibody.
Blue : DAPI
Dilution : 1:100

Anti-Tyrosinase antibody used in IHC (Paraffin sections) (IHC-P). GTX16389

GTX16389 IHC-P Image

IHC-P analysis of human skin cancer tissue using GTX16389 Tyrosinase antibody.
Blue : DAPI
Dilution : 1:100

Anti-Tyrosinase antibody used in IHC (Paraffin sections) (IHC-P). GTX16389

GTX16389 IHC-P Image

IHC-P analysis of rat skin tissue using GTX16389 Tyrosinase antibody.
Blue : DAPI
Dilution : 1:100

Anti-Tyrosinase antibody used in IHC (Paraffin sections) (IHC-P). GTX16389

GTX16389 IHC-P Image

IHC-P analysis of rat heart tissue using GTX16389 Tyrosinase antibody.
Dilution : 1:100

REFERENCE

Application Reference

Y Lan et al. Br J Dermatol 2021; 185 (2) : 391-404 Opsin 5 is a key regulator of ultraviolet radiation-induced melanogenesis in human epidermal melanocytes.
Application : WB
Reactivity : Human
?cie?y?ska A et al. Cancers (Basel) 2021; 13 (24) A Novel and Effective Method for Human Primary Skin Melanocytes and Metastatic Melanoma Cell Isolation.
Hseu YC et al. Redox Biol 2021; 44 : 102007 The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated α-MSH in keratinocytes via Nrf2-mediated antioxidant pathways.
Application : WB
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399